AI is revolutionizing healthcare in Japan and East Asia, addressing aging populations, healthcare costs, and accessibility challenges. AI-driven precision medicine enhances early disease detection and personalized treatment, as seen in Japan’s RIKEN Institute and South Korea’s AI diagnostic tools. Robotics and smart home monitoring systems are reshaping elderly care, while AI-driven drug discovery accelerates pharmaceutical innovation. However, responsible AI deployment requires robust policies ensuring data equity, privacy protection under APPI and PIPA, and AI literacy among medical professionals. Public-private collaborations can drive affordability and accessibility, ensuring AI bridges healthcare gaps rather than widens them. By embedding AI within ethical and inclusive frameworks, Japan and East Asia can lead the next era of global healthcare innovation while ensuring precision, accessibility, and governance-driven impact.