Japan and East Asia are at the forefront of AI-driven healthcare transformation, integrating cutting-edge innovations to tackle demographic and systemic challenges. AI-powered diagnostics and predictive modeling enhance precision medicine, optimizing treatment plans and reducing healthcare burdens. Robotic-assisted care and AI-driven monitoring technologies address the region’s aging crisis, ensuring dignified, independent living for seniors. AI is also reshaping pharmaceutical innovation, accelerating drug development through machine learning-driven bioinformatics. However, this progress demands ethical governance, reinforced regulatory frameworks, and AI literacy among healthcare professionals. Policymakers must enforce stringent data privacy protections under APPI and PIPA while fostering cross-sector collaboration to make AI-driven healthcare widely accessible. A harmonized, policy-driven AI strategy will not only future-proof Japan’s and East Asia’s healthcare systems but also set a global benchmark for ethical, intelligent, and equitable medical innovation.