Science, Technology, Engineering and Innovation Policy form a critical part of the comprehensive set of policy measures needed to trigger the transition of these socio-technical systems to meet global challenges. However, this calls for a re-think in government policymaking that takes a more systemic view of problems and an inclusive and holistic approach to STI policy interventions. While governments are already implementing relevant policies and governance arrangements, they need to be more ambitious and act with greater urgency in their STI policies.