Preventive healthcare is vital for mitigating the growing burden of chronic diseases in Japan and beyond. Rising healthcare costs, aging populations, and lifestyle shifts necessitate a shift from reactive to proactive care. AI-driven predictive analytics, early screenings, and digital health interventions can transform chronic disease management. Policies must mandate routine health screenings, integrate AI-powered diagnostics, and promote digital health adoption through national insurance frameworks. Governments should incentivize healthy lifestyles via tax benefits for preventive programs and corporate wellness initiatives. Expanding telemedicine and AI-driven health monitoring will enhance accessibility and efficiency. Strict regulations must ensure data privacy and ethical AI deployment under laws like Japan’s APPI and South Korea’s PIPA. By embedding prevention into healthcare policies, Japan and East Asia can lead globally in sustainable, proactive healthcare solutions.